ABSTRACT
Plant, mineral, and animal products have been utilized as medications from the beginning of time to cure a variety of ailments. Use of medicinal herbs to modulate immune function has a rich history. Natural products serve as the foundation for contemporary pharmaceutical ingredients. Immunomodulation alters an individual's immune system by interfering with its normal processes. Immunomodulators derived from natural sources have been extensively studied in order to modify the immune system and prevent illness. Berberine is an alkaloid has been identified for its anti-inflammatory properties. In animal studies, Berberine was found to demonstrate analgesic properties. The current work is aimed to explore the in silico interactions of Berberine with various chemokines and inflammatory pathways. Berberine was docked with TNF-?, IL-1?, IL-6, and NOs in this investigation. Docking study demonstrated notable interactions with these targets. The present research provides insight into the development of new compounds for immunomodulation and the management of inflammatory illnesses. More research on Berberine and related flavonoids is necessary to assess its safety. As a result, Berberine can be regarded as a candidate for the advancement of an immunomodulatory agent.
ABSTRACT
Forms eternal era, plant, mineral and animal products are used as drugs for the treatment of various diseases. The use of medicinal plants for immunomodulation has a long history. The modern medicinal compounds find their leads in natural products. Immunomodulation amends the immune system of an individual by prying with its usual functions. Discovery of immunomodulators from natural sources has been comprehensively made to modulate the immune system to prevent diseases. Hesperidin has been investigated for its potential anti-inflammatory effects. Hesperidin demonstrated analgesic effects in experimental animals. The present study is focused on exploring the in silico interaction of hesperidin with some chemokines and inflammatory targets. In this study, hesperidin was docked with TNF-α, IL-1β, IL-6, and NOs. Docking studies revealed the excellent interaction of hesperidin with these targets. The result of this work provided an insight into the discovery of novel molecules for immunomodulation and treatment of inflammatory disorders. Additional studies on hesperidin and associated flavonoids are necessary to establish its safety. Hesperidin, can, therefore, can be considered as a candidate for development of an immunomodulatory agent.
ABSTRACT
The modern scientific society has presently recognized flavonoids to be a unique class of therapeutic molecules due to their varied therapeutic properties. Of these, hesperidin, found along with vitamin C, has been explored for a number of pharmacological effects. Citrus and oranges possess hesperidin as one of the active constituents. Today, hesperidin has been well recognized for its beneficial effects on health. The present review highlights the current information and health-promoting effects of hesperidin. The review uncovers protective effects of hesperidin on functions and integrity of liver, kidney, heart, and age related memory impairment. Hesperidin demonstrated the antimicrobial, anticancer, antihypertensive and antiulcer effect. The present review focus on current information of hesperidin and its active metabolite hesperetin. Along with this, the chemotherapeutic potential of the same has also discussed.
ABSTRACT
The use of plant products as immunomodulator has a long history. Forms eternal era, plant, mineral and animal products are used as drugs for the treatment of various diseases. The present-day synthetic compounds find their leads in natural products. The process of immunomodulation retunes the immune system of an individual by restoring routine functions. Research on immunomodulators from natural sources has been extensively studied for modulation of immune system along with protection and prevention of diseases. Rutin, a flavonoid has been investigated for its potential immunomodulatory effects. Increased particle clearance, decreased inflammation, increased leucocyte and antibody production was observed with administration of rutin in rats. The present study is focused on exploring in silico interaction of rutin with some chemokines and inflammatory targets. In this study, rutin was docked with TNF-α, IL-1β, IL-6, and NOs. Docking studies revealed the excellent interaction of rutin with these targets. The result of present study provides insight for the discovery of novel molecules for immunomodulation and treatment of inflammatory disorders. Findings from the present study show that rutin may interact with several chemokines and inflammatory mediators. Further studies on rutin and associated flavonoids are necessary to develop and establish QSAR and QSPR studies which may serve a stepping stone for the development of novel and safe immunomodulator. Rutin therefore, can be considered for development of an immunomodulatory agent.
ABSTRACT
Aim of Study: The aim of current work was to evaluate in vitro anticataract potential of Moringa oliefera extract. Materials and Methods: Goat eye lenses were divided into 4 groups; Group served as control, Group II as toxic control, Group III and Group IV were incubated in extract (250 μg/ml and 500 μg/ml of extract of M. oliefera) Group II, III and IV were incubated in 55 mM glucose in artificial aqueous humor to induce lens opacification. Estimation of total, water soluble protein, catalase, glutathione and malondialdehyde along with photographic evaluation of lens was done. Results: Group II (toxic control) lenses showed high amount of MDA (Malondialdehyde), soluble, insoluble protein, decreased catalase and glutathione levels, while lenses treated with Moringa oliefera extract (Group III and Group IV) showed significant (*P < 0.05) reduction in MDA and increased level of catalase, glutathione, total and soluble protein. Conclusion: Results of present findings suggest protective effect of Moringa oliefera in prevention of in vitro glucose induced cataract.